Dr. Guerriero received his PhD in 2008 in Cell Biology and Molecular Physiology from his work in Ora Weisz's Lab at the University of Pittsburgh School of Medicine. In 2009, Dr. Guerriero started his postdoctoral studies in Jeff Brodsky's lab in the Department of Biological Sciences at the University of Pittsburgh. In 2014, Dr. Guerriero was promoted to research assistant professor.
Dr. Guerriero's PhD research focused on the role of lipid metabolism in biosynthetic protein trafficking in polarized epithelial cells. This research spawned his interest in the folding and trafficking decisions that occur early in the biosynthetic pathway. In 2009, he joined Dr. Jeff Brodsky's lab to study the mechanisms that select and target misfolded proteins for degradation in the secretory pathway, termed ER-associated Degradation (ERAD).
Currently, Dr. Guerriero's research is focused on understanding the quality control machinery that recognizes misfolded membrane-spanning proteins. His research has recently expanded to include computational modeling of ERAD substrate hydrophobicity and how it impacts the degradation process.